General information:
Substance group: Antiarrhythmic Class III ATC: C01BD01
Trade names: Amio-*®, Cordarex®, Cornaron®
available doses: tablets 100 / 200 mg, solution for injection 50 mg/mL
Reference ranges:
Amiodarone: 0.5 – 2.5 mg/L
Desethylamiodaron: 0,5 – 3.0 mg/L
Toxic Plasma levels: Amiodarone 2.5 – 3.0 mg/L
Pharmacokinetics:
T1⁄2 : 20–60 days
Tmax : 4–6 h
Bioavailability: 40–50%
Protein binding: 96%
Clearance: 140 mL/min
Excretion: Faeces: 90%; Urine: 10%
Metabolism: hepatic
Distribution volume: 66 L/kg KG
Time to steady state: 100–150 days
Sampling:
Material: Serum (Monovette brown) Minimum volume for analysis: 50µl
Recommendation: trough level (directly before the next intake)
Requirement (internal): … requirement (external):
PharmAnalytics:
Test principle: liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)
Protein precipitation with acetonitrile, chromatographic separation, mass spectrometry
Analysis according to mass charge ratio
Analysis system: triple stage Quadrupol mass spectrometer (LC-MS/MS)
Findings communication: on the day of the Eibroadcast, via LIMS
DrugBank: https://go.drugbank.com/drugs/DB01118