Nortriptyline

General information:
Substance group: Tri-cyclic antidepressant, Metabolite of Amitriptyline ATC: N06AA10
Trade names: Nortrilen®
Available dosage form: Dragees 10 / 25 mg
Reference ranges:
Amitriptyline: 50 – 200 µg/L
Nortriptyline: 20 – 200 µg/L
Amitriptyline + Nortriptyline: 80 – 200 µg/L
Plasma levels associated with risk of adverse events: the risk of malicious excitation in excitation disturbances increases from 300 – 400 µg/L
Toxic plasma levels: Amitriptyline: 500 µg/L – 750 µg/L
Nortriptyline: 300 µg/L
Sampling:
Material: Serum (Monovette brown) Minimum volume for analysis: 50µL
Recommendation: trough level (directly before the next intake)
Requirement (internal): via… requirement (external):
Pharmacology:
Test principle: liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)
Protein precipitation with acetonitrile, chromatographic separation, mass spectrometry
Analysis according to mass charge ratio
Analysis system: triple stage Quadrupol mass spectrometer (LC-MS/MS)
Findings communication: on the day of submission, via LIMS