General information:
Substance group: Antiepileptic drugs ATC: N03AF02
Trade names: Apydan®, Timox®, Trileptal®, Oxcarbazepin*®
available dosages: film tablets 150 / 300 / 600 mg, retard pills 150 / 300 / 600 mg,
Suspension 60 mg/ml
Reference ranges:
10 – 35 mg/l (maximum plasma level)
Toxic Plasma levels: 45 mg/l
Sampling:
Material: Serum (Monovette brown) Minimum volume for analysis: 500µl
Recommendation: trough level (directly before the next intake)
Requirement (internal): about Orbis requirement (external):
Pharmacology:
Test principle: High-performance liquid chromatography with UV detection (HPLC-UV)
Liquid-liquid extraction with ether, chromatographic separation, absorption measurement
Analysis system: HPLC
Findings communication: on the day of submission, via LIMS
Indication:
Level 2: TDM recommended
TDM at least every 3-6 months or more frequently in case of dose titration, suspected non-adherence, dose changes, changes in comedic eradication, adverse drug effects, intoxication, pregnancy, change in kidney function or simultaneous use of enzyme inducing/- inhibiting drugs.
DrugBank: https://go.drugbank.com/drugs/DB00776