General information:
Substance group: Antifungal ATC: J02AC01
Trade names: Fluconazol-*®, Diflucan®, Flucoderm®, Flunazul®, Fungata®
available dosages: hard capsules 50 / 100 / 150 / 200 mg, solution for taking 5 mg/mL,
Infusion solution 2 mg/mL
Reference ranges:
1-5 (-15) mg/L
Toxic Plasma levels: >20 (95) mg/L
Pharmacokinetics:
T 1⁄2 : 27 – 37 h (Children: 15 – 18 h)
T max : 0.5 – 1.5 h
Bioavailability: > 90%
Protein binding: 12%
Clearance: 20 mL/min
Excretion: urine
Metabolism: about 11%
Distribution volume: 0.71 L/kg (children: 0.88 l/kg)
Time to steady state: 4 – 5 days
Sampling:
Material: Serum (Monovette brown) Minimum volume for analysis: 500µl
Recommendation: trough level (directly before the next intake)
Requirement (internal): … requirement (external):
Analytics:
Test principle: liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)
Protein precipitation with acetonitrile, chromatographic separation, mass spectrometry
Analysis according to mass charge ratio
Analysis system: triple stage Quadrupol mass spectrometer (LC-MS/MS)
Findings release: on the same working day, via LIMS
Indication:
TDM not necessarily routinely recommended
TDM useful in patients with renal dysfunction.
DrugBank: https://go.drugbank.com/drugs/DB00196