General information:
Substance group: Antifungal ATC: J02AC02
Trade names: Itraconazole-*®, Itraderm®, Itraisidin®, Sempera®, Siros®
available dosages: hard capsules 50 / 100 mg, solution for taking 10 mg/mL,
Infusion solution 10 mg/mL
Reference ranges:
0.4 – 2.0 mg/L
Toxic plasma levels: n.a.
Pharmacokinetics:
T 1⁄2 : 17 h (single adminsitration) – 42 h
T max: 2 – 5 h (oral)
Bioavailability: 55% (fastened: 85%)
Protein binding: 99.8%
Clearance: 380 mL/min
Excretion: urine: 35%, faeces: 54%
Metabolism: hepatic
Distribution volume: 11 L/kg
Time to steady state: 15 days
Sampling:
Material: Serum (Monovette brown) Minimum volume for analysis: 50µl
Recommendation: trough level (directly before the next intake)
Requirement (internal): … requirement (external):
Test principle: liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)
Protein precipitation with acetonitrile, chromatographic separation, mass spectrometry
Analysis according to mass charge ratio
Analysis system: triple stage Quadrupol mass spectrometer (LC-MS/MS)
Findings release: on the same working day, via LIMS
Indication:
TDM is recommended.
TDM at least every 3-6 months or more frequently in case of dose titration, suspected non-adhesion, dose changes, changes in comedic eradication, adverse drug effects, insufficient clinical improvement.
DrugBank: https://go.drugbank.com/drugs/DB01167