General information:
Substance group: Tri-cyclic antidepressant ATC: N06AA04
Trade names: Clomiprice*®, Anafranil®
available doses: film tablets 10 / 25 mg, retarding tablet 75 mg
Reference ranges:
Clomipramine: (20) 90–250 (400) µg/L
Clomipramine + Norclomipramine: 230–450 µg/L
Toxic Plasma Levels:
Clomipramine: from 400–600 µg/L
Clomipramine + Norclomipramine: > 450 µg/L
Pharmacokinetics:
T1⁄2 : 12 – 36 h (metabolite: 36 h)
T max : 3 – 4 h (retard: 5 – 8 h)
Bioavailability: 50% (retard: 90%)
Protein binding: 98%
Clearance: 750 mL/min
Excretion: urine: 66%; faeces: 33%
Metabolism: hepatic
Distribution volume: 12 L/kg KG
Time to steady state: 7 days
Sampling:
Material: Serum (Monovette brown) Minimum volume for analysis: 500µl
Recommendation: trough level (directly before the next intake)
Requirement (internal): … requirement (external):
Analytics:
Test principle: liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)
Protein precipitation with acetonitrile, chromatographic separation, mass spectrometry
Analysis according to mass charge ratio
Analysis system: triple stage Quadrupol mass spectrometer (LC-MS/MS)
Findings release: on the same working day, via LIMS
DrugBank: https://go.drugbank.com/drugs/DB01242