General information:
Drug Class: Atypical fresh-wrneoptic ATC: N05AH02
Trade names: Clozapin*®, Leponex®, Elcrit®
available dosages: tablets 25 / 50 / 100 / 200 mg, suspension to take 50 mg/mL
Reference ranges:
350 – 600 µg/L
Toxic plasma level: >1000 µg/L
Pharmacokinetics:
T1⁄2 : 12 h (6 – 26 h)
Tmax : 2,1 h (0.4 – 4.2 h)
Bioavailability: 50 – 60%
Protein binding: 95%
Clearance: 13 – 57.5 L/h
Excretion: urine: 50%; faeces: 30%
Metabolism: hepatic
Distribution volume: 1.6 L/kg KG
Time to steady state: 10 days
Sampling:
Material: Serum (Monovette brown) Minimum volume for analysis: 500µl
Recommendation: trough level (directly before the next intake)
Requirement (internal): about Orbis requirement (external):
Analytics:
Test principle: liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)
Protein precipitation with acetonitrile, chromatographic separation, mass spectrometry
Analysis according to mass charge ratio
Analysis system: triple stage Quadrupol mass spectrometer (LC-MS/MS)
Findings release: on the same working day, via LIMS
DrugBank: https://go.drugbank.com/drugs/DB00363