General information:
Drug class: Tricyclic antidepressant ATC: N06AA02
Trade names: Imipramin-*®, Tofranil®
available dosages: film tablets 10 / 25 / 100 mg
Reference ranges:
50 – 350 µg/L
Toxic plasma levels: 500 –1000 µg/L
Pharmacokinetics:
T1⁄2 : 6 – 20 h (metabolite: 15 – 25 h)
Tmax : 2 h
Bioavailability: 22 – 77%
Protein binding: 90%
Clearance: 1 L/min
Excretion: urine: 70%, faeces: 22%
Metabolism: hepatic
Distribution volume: 11.5 L/kg respectively 21 L/kg
Time to steady state: 2 – 5 days
Sampling:
Material: Serum (Monovette brown) Minimum volume for analysis: 500µl
Recommendation: trough level (directly before the next intake)
Requirement (internal): … requirement (external):
Analytics:
Test principle: liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)
Protein precipitation with acetonitrile, chromatographic separation, mass spectrometry
Analysis according to mass charge ratio
Analysis system: triple stage Quadrupol mass spectrometer (LC-MS/MS)
Findings release: on the same working day, via LIMS
Indication:
Level 1: TDM strongly recommended
TDM at least every 3-6 months or more frequently in case of dose titration, suspected non-adhesion, dose changes, changes in comedic eradication, adverse drug effects, insufficient clinical improvement.
DrugBank: https://go.drugbank.com/drugs/DB00458