General information:
Substance group: Anticonvulsant ATC: N03AX14
Trade names: Keppra®, Kevesy®, Levetiragamma®, Levetiracetam-*®
available dosages: film tablets 250 / 500 / 750 / 1000 mg, solution for taking 100 mg/mL,
Infusion solution 5 / 10 / 15 / 100 mg/mL, filmed granules 250 / 375 / 500 / 750 / 1000 / 1250 / 1500 mg
Reference ranges:
10 – 40 mg/L
Toxic Plasma level: >100 mg/L
Pharmakokinetics:
T½: 7 h
Tmax: 1,3 h
Bioavailability: 100%
Protein binding: < 10%
Clearance: 0,96 mL/min
Elimination: Urin: 95%
Metabolism: 24% im Blut
Distribution volume: 0,5 – 0,7 L/kg KG
time to steady-state: 2 days
Sampling:
Material: Serum (Monovette brown) Minimum volume for analysis: 500µl
Recommendation: trough level (directly before the next intake)
Requirement (internal): … requirement (external):
Analytics:
Test principle: liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)
Protein precipitation with acetonitrile, chromatographic separation, mass spectrometry
Analysis according to mass charge ratio
Analysis system: triple stage Quadrupol mass spectrometer (LC-MS/MS)
Findings communication: on the day of submission, via LIMS