General information:
Drug class: Antipsychotic, atypical neuroroleptic drug ATC: N05AH03
Trade names: Zyprexa®, Zypadhera®, Lybalvi, Olazax, Symbyax, Zalasta,
available dosages : Tablets 2.5 / 5 / 7.5 / 10 / 15 / 20 mg
Reference ranges:
20-80 µg/L
Toxic plasma levels: from 100 µg/l
Sampling:
Material: Serum (Monovette brown) Minimum volume for analysis: 50µL
Recommendation: trough level (directly before the next intake)
Requirement (internal): via LIMS requirement (external):…
Pharmacology:
Test principle : Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)
Protein precipitation with acetonitrile, chromatographic separation, mass spectrometry
Analysis according to mass charge ratio
Analysis system : HPLC-LC-MS/MS-triple stage Quadrupol mass spectrometer
Findings : on the same working day, via LIMS
DrugBank: https://go.drugbank.com/drugs/DB00334